IGF DES
DES(1-3) IGF-1 DESCRIPTION
Protein DES(1-3) IGF-1 is a truncated version of peptide hormone IGF-1 (insulin-like growth factor 1) in which the tripeptide Gly-Pro-Glu is absent from the N-terminus end of the protein. In other words, DES(1-3) IGF-1 lacks the first 3 amino acids at the N-terminus of insulin-like growth factor 1, and consists from total of 67 amino acids, relative to the 70 amino acids of IGF-1.
It is naturally occurring endogenous hormone in human and mammals, that has been found in the human brain, cow colostrum, and pig uterine tissue. The amino acid sequence of DES(1-3) IGF-1 is TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SSRRAPQTGI VDECCFRSCD LRRLEMYCAP LKPAKSA.
CLINICAL TRIALS AND DES(1-3) IGF-1 RESULTS
Scientific research and clinical trials have shown, that DES(1-3) IGF-1 binds with high-affinity to IGF-1 receptor. And thanks to its a much reduced binding to IGF-binding proteins, caused by the absence of the glutamate at position 3 (tripeptide Gly-Pro-Glu at the N-terminus) is even 10-fold more potent than regular IGF-1 in stimulating hypertrophy and proliferation of cells!
Clinical opportunities for DES(1-3) IGF-1 have not yet been very evaluated, but could apply in catabolic states (using the peptide to induce anabolism in catabolic conditions such as muscular dystrophy) as well as for the treatment of inflammatory bowel diseases. IGF-1 has a strong ability to maintain and build muscle, especially DES(1-3) IGF-1 form. In addition to a direct anabolic effect on skeletal muscle, the production of more IGF-I is also capable of stimulating the proliferation and differentiation of muscle stem cells (satellite cells) – real growth of new muscle cells, and IGF-1 is the only hormone that can do this. DES(1-3) IGF-1 is also promising candidate for treat of a number of neurological diseases.
SCIENTIFICALLY INVESTIGATED POSSIBLE BENEFITS OF DES(1-3) IGF-1
Overall regeneration of the whole body (incl. internal organs), increased cellular repair
Anti-aging effects, rejuvenation and the ability to slow-down the aging
Increased collagen production, healthier skin, helping to smooth out wrinkles
Strong anabolic effect / promoting muscle growth, strength and performance
Ability to induce muscle hyperplasia – the growth of new muscle cells
Strong anti-catabolic effect / protection against muscle wasting
Increased bone mineral content / greater bone mineral density
Improved cognitive functions, improves learning and memory
Promotes regeneration of the nervous system and brain health
May reduce risk of heart & cardio-vascular diseases
Strengthened immune system
Anti-inflammatory effects
Improved gut health
DES(1-3) IGF-1 POSSIBLE SIDE-EFFECTS
Possible correlation insulin-like growth factor 1 to certain forms of cancer development (however, performed studies are often unclear, and
often with conflicting or very different results)
Risk for diabetes (performed studies are often unclear)
Low blood sugar
Joint pain
Nausea
Acne
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Description
DES(1-3) IGF-1 DESCRIPTION
Protein DES(1-3) IGF-1 is a truncated version of peptide hormone IGF-1 (insulin-like growth factor 1) in which the tripeptide Gly-Pro-Glu is absent from the N-terminus end of the protein. In other words, DES(1-3) IGF-1 lacks the first 3 amino acids at the N-terminus of insulin-like growth factor 1, and consists from total of 67 amino acids, relative to the 70 amino acids of IGF-1.
It is naturally occurring endogenous hormone in human and mammals, that has been found in the human brain, cow colostrum, and pig uterine tissue. The amino acid sequence of DES(1-3) IGF-1 is TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SSRRAPQTGI VDECCFRSCD LRRLEMYCAP LKPAKSA.
CLINICAL TRIALS AND DES(1-3) IGF-1 RESULTS
Scientific research and clinical trials have shown, that DES(1-3) IGF-1 binds with high-affinity to IGF-1 receptor. And thanks to its a much reduced binding to IGF-binding proteins, caused by the absence of the glutamate at position 3 (tripeptide Gly-Pro-Glu at the N-terminus) is even 10-fold more potent than regular IGF-1 in stimulating hypertrophy and proliferation of cells!
Clinical opportunities for DES(1-3) IGF-1 have not yet been very evaluated, but could apply in catabolic states (using the peptide to induce anabolism in catabolic conditions such as muscular dystrophy) as well as for the treatment of inflammatory bowel diseases. IGF-1 has a strong ability to maintain and build muscle, especially DES(1-3) IGF-1 form. In addition to a direct anabolic effect on skeletal muscle, the production of more IGF-I is also capable of stimulating the proliferation and differentiation of muscle stem cells (satellite cells) – real growth of new muscle cells, and IGF-1 is the only hormone that can do this. DES(1-3) IGF-1 is also promising candidate for treat of a number of neurological diseases.
SCIENTIFICALLY INVESTIGATED POSSIBLE BENEFITS OF DES(1-3) IGF-1
Overall regeneration of the whole body (incl. internal organs), increased cellular repair
Anti-aging effects, rejuvenation and the ability to slow-down the aging
Increased collagen production, healthier skin, helping to smooth out wrinkles
Strong anabolic effect / promoting muscle growth, strength and performance
Ability to induce muscle hyperplasia – the growth of new muscle cells
Strong anti-catabolic effect / protection against muscle wasting
Increased bone mineral content / greater bone mineral density
Improved cognitive functions, improves learning and memory
Promotes regeneration of the nervous system and brain health
May reduce risk of heart & cardio-vascular diseases
Strengthened immune system
Anti-inflammatory effects
Improved gut health
DES(1-3) IGF-1 POSSIBLE SIDE-EFFECTS
Possible correlation insulin-like growth factor 1 to certain forms of cancer development (however, performed studies are often unclear, and
often with conflicting or very different results)
Risk for diabetes (performed studies are often unclear)
Low blood sugar
Joint pain
Nausea
Acne
